A structure-based gamma evaluation method for identifying clinically relevant dose differences in organs at risk.

Gamma evaluation is currently the most widely used dose comparison method for patient specific quality assurance (PSQA). However, existing methods for normalising the dose difference, using either the dose at the global maximum dose point or at each local point, can respectively lead to under- and over-sensitivity to dose differences in organ-at-risk structures. This may be of concern for plan evaluation from clinical perspectives. This study has explored and proposed a new method called structural gamma, which takes structural dose tolerances into consideration while performing gamma analysis for PSQA. As a demonstration of the structural gamma method, a total of 78 retrospective plans on four treatment sites were re-calculated on an in-house Monte Carlo system and compared with doses calculated from the treatment planning system. Structural gamma evaluations were performed using both QUANTEC dose tolerances and radiation oncologist specified dose tolerances, then compared with conventional global and local gamma evaluations. Results demonstrated that structural gamma evaluation is especially sensitive to errors in structures with restrictive dose constraints. The structural gamma map provides both geometric and dosimetric information on PSQA results, allowing straightforward clinical interpretation. The proposed structure-based gamma method accounts for dose tolerances for specific anatomical structures. This method can provide a clinically useful method to assess and communicate PSQA results, offering radiation oncologists a more intuitive way of examining agreement in surrounding critical normal structures.

Webinar and survey on quality management principles within the Australian and New Zealand ACPSEM Workforce.

Healthcare relies upon the accurate and safe delivery of patient care. This is only achievable when systems are developed to ensure high quality, robust outcomes, for instance quality management systems. The concept of quality management can take on a different meaning depending on the context in which it is found. To add complication, the amount of education required for quality management will vary depending on one's exposure to the implementation of quality systems. In part to address these issues, the Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM) Queensland Branch held a quality management webinar for members and non-members across Australia and New Zealand. The purpose of the webinar was to educate and facilitate discussion regarding the application of quality management principles for the ACPSEM profession. In conjunction, a pre- and post-webinar survey was conducted to gain an insight into existing knowledge and attitudes within the professions governed by the ACPSEM and students undertaking related studies. This paper authored by the webinar speakers reintroduces the quality management principles that were discussed in webinar, exemplifies the importance of quality management skills within the ACPSEM professions and presents the results of the surveys, promoting the need for more educational resources on quality management tools.

Development of a customisable 3D-printed intra-oral stent for head-and-neck radiotherapy.

Intra-oral stents (including mouth-pieces and bite blocks) can be used to displace adjacent non-involved oral tissue and reduce radiation side effects from radiotherapy treatments for head-and-neck cancer. In this study, a modular and customisable 3D printed intra-oral stent was designed, fabricated and evaluated, to utilise the advantages of the 3D printing process without the interruption of clinical workflow associated with printing time. The stent design used a central mouth-opening and tongue-depressing main piece, with optional cheek displacement pieces in three different sizes, plus an anchor point for moulding silicone to fit individual patients' teeth. A magnetic resonance imaging (MRI) study of one healthy participant demonstrated the tissue displacement effects of the stent, while providing a best-case indication of its comfort.

A publicly available dataset of out-of-field dose profiles of a 6 MV linear accelerator.

An increase in radiotherapy-induced secondary malignancies has led to recent developments in analytical modelling of out-of-field dose. These models must be validated against measurements, but currently available datasets are outdated or limited in scope. This study aimed to address these shortcomings by producing a large dataset of out-of-field dose profiles measured with modern equipment. A novel method was developed with the intention of allowing physicists in all clinics to perform these measurements themselves using commonly available dosimetry equipment. A standard 3D scanning water tank was used to collect 36 extended profiles. Each profile was measured in two sections, with the inner section measured with the beam directly incident on the tank, and the outer section with the beam incident on a water-equivalent phantom abutted next to the tank. The two sections were then stitched using a novel feature-matching approach. The profiles were compared against linac commissioning data and manually inspected for discontinuities in the overlap region. The dataset is presented as a publicly accessible comma separated variable file containing off-axis ratios at a range of off-axis distances. This dataset may be applied to the development and validation of analytical models of out-of-field dose. Additionally, it may be used to inform dose estimates to radiosensitive implants and anatomy. Physicists are encouraged to perform these out-of-field measurements in their own clinics and share their results with the community.

3D printed brachytherapy jig for Reference Air Kerma Rate calibration.

3D printing in modern radiotherapy allows users the ability to create custom devices which can be a valuable tool for use in brachytherapy source calibration. Radiotherapy centres may verify their brachytherapy source activity with a calibrated Farmer chamber. For this purpose, a jig was designed, 3D printed and commissioned for in-air source strength calibration. Measurements on four afterloaders with varied equipment and environments were completed. A full uncertainty budget was developed and measurements with the in-air jig were consistently within 3% of the certificate source strength, and within the 4.1% combined uncertainty for comparing a well chamber measurement (1.7%) with the in air jig (3.75%). By creating a jig that is able to be customised to multiple catheter sizes and cylindrical chamber designs, centres can be provided with the option of independently checking their source strength with ease and for little cost.

Dosimetric evaluation of a patient-specific 3D-printed oral positioning stent for head-and-neck radiotherapy.

As head-and-neck radiotherapy treatments become more complex and sophisticated, and the need to control and stabilise the positioning of intra-oral anatomy becomes more important, leading the increasing use of oral positioning stents during head-and-neck radiotherapy simulation and delivery. As an alternative to the established practice of creating oral positioning stents using wax, this study investigated the use of a 3D printing technique. An Ender 5 3D printer (Creality 3D, Shenzhen, China) was used, with PLA+ "food-safe" polylactic acid filament (3D Fillies, Dandenong South, Australia), to produce a low-density 3D printed duplicate of a conventional wax stent. The physical and dosimetric effects of the two stents were evaluated using radiochromic film in a solid head phantom that was modified to include flexible parts. The Varian Eclipse treatment planning system (Varian Medical Systems, Palo Alto, USA) was used to calculate the dose from two different head-and-neck treatment plans for the phantom with each of the two stents. Examination of the resulting four dose distributions showed that both stents effectively pushed sensitive oral tissues away from the treatment targets, even though most of the phantom was solid. Film measurements confirmed the accuracy of the dose calculations from the treatment planning system, despite the steep density gradients in the treated volume, and demonstrated that the 3D print could be a suitable replacement for the wax stent. This study demonstrated a useful method for dosimetrically testing novel oral positioning stents. We recommend the development of flexible phantoms for future studies.

Measuring foetal dose from tomotherapy treatments.

INTRODUCTION: Treating pregnant women in the radiotherapy clinic is a rare occurrence. When it does occur, it is vital that the dose received by the developing embryo or foetus is understood as fully as possible. This study presents the first investigation of foetal doses delivered during helical tomotherapy treatments. Six treatment plans were delivered to an anthropomorphic phantom using a tomotherapy machine. These included treatments of the brain, unilateral and bilateral head-and-neck, chest wall, and upper lung. Measurements of foetal dose were made with an ionisation chamber positioned at various locations longitudinally within the phantom to simulate a variety of patient anatomies. All measurements were below the established limit of 100 mGy for a high risk of damage during the first trimester. The largest dose encountered was 75 mGy (0.125% of prescription dose). The majority of treatments with measurement positions less than 30 cm fell into the range of uncertain risk (50 - 100 mGy). All treatments with measurement positions beyond 30 cm fell into the low risk category (< 50 mGy). For the cases in this study, tomotherapy resulted in foetal doses that are at least on par with, if not significantly lower than, similar 3D conformal or intensity-modulated treatments delivered with other devices. Recommendations were also provided for estimating foetal doses from tomotherapy plans.

Technical Note: Small field dose correction factors for radiochromic film in lung phantoms.

PURPOSE: Radiochromic film has been established as a detector that can be used without the need for perturbation correction factors for small field dosimetry in water. However, perturbation factors in low density media such as lung have yet to be published. This study calculated the factors required to account for the perturbation of radiochromic film when used for small field dosimetry in lung equivalent material. METHOD: Monte Carlo simulations were used to calculate dose to Gafchromic EBT3 film when placed inside a lung phantom. The beam simulated had a nominal energy of 6 MV and the field sizes simulated ranged from 10 × 10 mm2 to 30 × 30 mm2 . The lung density simulated was varied between 0.2 and 0.3 g/cm3 . Each simulation was repeated with the film replaced by lung material (the same as the surrounding medium), and the required correction factors for film dosimetry in lung ( D M e d , Q D D e t , Q ) were calculated by dividing the dose in lung by the dose in film. RESULTS: For field sizes 30 × 30 mm2 and larger, no correction factors were required. At a 20 × 20 mm2 field size, small corrections were required, but were within the approximate accuracy of film dosimetry (~2%). For a 10 × 10 mm2 field size, significant correction factors need to be applied (0.935 for lung density of 0.20 g/cm3 to 0.963 for lung density of 0.30 g/cm3 ). The values lower than one mean that the film is over-responding. At the "upstream" lung-water interface the correction factors were close to unity; while at the downstream interface the corrections required were marginally smaller to those at the center of lung. One centimeter or more away from the interfaces, the correction factor did not vary as a function distance from the interface (in the beam direction). Away from the central axis (perpendicular to the beam direction), the correction factors increased slightly (away from unity) as a function of off-axis distance, before abruptly changing direction at the penumbra, with the film actually under-responding by ~10% outside the field edges. CONCLUSION: Accurate dosimetry of very small fields (15 × 15 mm2 or smaller) using radiochromic film requires correction factors for the perturbation of the film on the surrounding lung material. This correction factor was as high as 6.5% for a 10 × 10 mm2 field size and a density of 0.2 g/cm3 . This will increase if either the density or the field size decrease further. This correction factor does not vary as a function of depth in lung once charged particle equilibrium is established.

Comparison of global and local gamma evaluation results using isodose levels.

The aim of this study is to evaluate the behaviour of global and local gamma analyses with isodose levels. Global and local gamma evaluation were performed on patient-specific quality assurance (PSQA) data from 100 volumetric modulated arc therapy (VMAT) arcs and 100 helical tomotherapy (HT) plans, using an in-house gamma code. Gamma pass rates versus isodose levels were plotted and evaluated. Other than a slightly increased skew towards higher pass rates for the global gamma evaluation, minimal differences were observed between the results of evaluating all VMAT arcs separately and the results of evaluating over VMAT treatment plans by combining arcs from each plan. Generally, the VMAT results showed average pass rates that increase with decreasing isodose level, for both global and local gamma evaluations. The HT results differed systematically from the VMAT results, with the results of performing global and local gamma evaluations agreeing more closely at all isodose levels and with the highest gamma pass rates being achieved at intermediate dose levels, between the 40 and 70% isodose levels. These results demonstrate the complex of relationships between global and local gamma evaluation results that can arise when clinical PSQA data are analysed and exemplify how the local gamma evaluation does not necessarily produce disproportionately reduced gamma pass rates in low dose regions. Performing gamma evaluation with different isodose levels is suggested as a useful method to improve understanding of specific PSQA data and as well as the broader features of gamma evaluation results.

Predicting the required thickness of custom shielding materials in kilovoltage radiotherapy beams.

The planning and delivery of kilovoltage (kV) radiotherapy treatments involves the use of custom shielding designed and fabricated for each patient. This study investigated methods by which the required thickness of custom shielding could be predicted for non-standard shielding materials fabricated using 3D printing techniques. Seven kV radiation beams from a WOmed T-300 X-ray therapy unit were modelled using SpekPy software, and AAPM TG-61 data were used to account for backscatter and spectral effects, for incrementally increasing thicknesses of Pb, W-PLA composite and Cu-PLA composite materials. The same beams were used to perform physical transmission measurements, and the thickness of each material required to achieve 5% beam transmission was determined. While the measured transmission factors for Pb, W-PLA and Cu-PLA shielding generally exceeded the calculated transmission factors, these differences had minimal effect on the derived thicknesses of shielding required to achieve 5% transmission, where calculations agreed with measurements within 0.5 mm for Pb at all available energies (70-300 kVp), within 1.4 mm for W-PLA at all available energies, and within 2.1 mm for Cu-PLA at superficial treatment energies (70-100 kVp). The incremental transmission factor calculation method described and validated in this study could be used, in combination with the conservative addition of 1-2 mm of additional material, to estimate shielding requirements for novel materials in therapeutic kilovoltage beams. However, if calculated shielding thicknesses equate to 10 mm or more, then additional verification measurements should be performed and the clinical suitability of the novel shielding material should be re-evaluated.

Effects of gas-filled temporary breast tissue expanders on radiation dose from modulated rotational photon beams.

Gas-filled temporary tissue expanders (TTEs), implanted to assist in post mastectomy breast reconstructions, are expected to produce increased dosimetric uncertainty in breast radiotherapy treatments, due to their containing both a substantial metallic component and a comparatively large volume of gas. This study therefore builds on previous investigations of the dosimetric effects of gas-filled TTEs in static photon and electron beams, by examining the effects of these implants on dose distributions from common modulated rotational treatment techniques; volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT). Radiochromic film measurements were used to evaluate the accuracy of VMAT and HT dose calculations, for a humanoid phantom augmented with a sample Aeroform CO2-filled TTE (AirXpanders Inc, San Jose, USA) as well as purpose-designed and 3D printed "breast tissue." Results showed that the TomoTherapy Hi-Art VoLO convolution-superposition algorithm (Accuray Inc, Sunnyvale, USA) produced comparatively accurate calculations of treatment dose within this complex phantom, including immediately anterior and posterior to the TTE. The Varian Eclipse Acuros (AXB) algorithm generally showed better agreement with the film measurement than the Varian Eclipse AAA algorithm (Varian Medical Systems, Palo Alto, USA), although the film measurements showed regions of 5% to 10% disagreement with both AAA and AXB in the dosimetrically-challenging region on the anterior side of the implant. Although the Aeroform CO2-filled TTE has substantial and obvious effects on the downstream dose from a static photon beam, the results of this study showed how inverse-planning of modulated rotational radiotherapy treatments can produce modulated fluence distributions that compensate for the dramatic density heterogeneities in the implant. Despite some disagreements with the planned dose, all film measurements showed that the use of inverse-planned modulated rotational photon beams resulted in comparatively homogeneous coverage of the radiotherapy target, in the complex patient-like phantom with a gas-filled TTE. Due to the importance of matching each planned fluence distribution to the density distribution within each TTE, careful use of available 3D imaging techniques is advisable, when modulated rotational radiotherapy treatments are delivered to patients with gas-filled TTEs.

Monte Carlo calculations of radiotherapy dose in "homogeneous" anatomy.

Given the substantial literature on the use of Monte Carlo (MC) simulations to verify treatment planning system (TPS) calculations of radiotherapy dose in heterogeneous regions, such as head and neck and lung, this study investigated the potential value of running MC simulations of radiotherapy treatments of nominally homogeneous pelvic anatomy. A pre-existing in-house MC job submission and analysis system, built around BEAMnrc and DOSXYZnrc, was used to evaluate the dosimetric accuracy of a sample of 12 pelvic volumetric arc therapy (VMAT) treatments, planned using the Varian Eclipse TPS, where dose was calculated with both the Analytical Anisotropic Algorithm (AAA) and the Acuros (AXB) algorithm. In-house TADA (Treatment And Dose Assessor) software was used to evaluate treatment plan complexity, in terms of the small aperture score (SAS), modulation index (MI) and a novel exposed leaf score (ELS/ELA). Results showed that the TPS generally achieved closer agreement with the MC dose distribution when treatments were planned for smaller (single-organ) targets rather than larger targets that included nodes or metastases. Analysis of these MC results with reference to the complexity metrics indicated that while AXB was useful for reducing dosimetric uncertainties associated with density heterogeneity, the residual TPS dose calculation uncertainties resulted from treatment plan complexity and TPS model simplicity. The results of this study demonstrate the value of using MC methods to recalculate and check the dose calculations provided by commercial radiotherapy TPSs, even when the treated anatomy is assumed to be comparatively homogeneous, such as in the pelvic region.

Exploring the gamma surface: A new method for visualising modulated radiotherapy quality assurance results.

PURPOSE: This work presents a novel method of visualising the results of patient-specific quality assurance (QA) for modulated radiotherapy treatment plans, using a three-dimensional distribution of gamma pass rates, referred to as the "gamma surface". The method was developed to aid in comparing borderline and failing QA plans, and to better compare patient-specific QA results between departments. METHODS: Gamma surface plots were created for a representative sample of situations encountered during patient-specific QA. To produce a gamma surface plot, for each QA result, gamma pass rates were plotted as a heat map, with dose difference on one axis and distance-to-agreement on the other. This involved the calculation of 100 × 100 gamma pass rates over a dose difference and distance-to-agreement grid. As examples, five 220 × 680 arrays of dose points from radiotherapy treatment plans were compared against measurement data consisting of 21 × 66 arrays of dose points spaced 10 mm apart. RESULTS: The gamma surface plots facilitated the rapid evaluation of criteria combinations for each plan, clearly highlighting the difference between plans that are modelled and delivered well, and those that are not. Large scale features were also evident in each surface, hinting at potential over-modulation, systematic dose errors, and small or large scale areas of disagreement in the distributions. CONCLUSIONS: Gamma surface plots are a useful tool for investigating QA failures and borderline results, and have the capacity to grant insights into treatment plan QA performance that may otherwise be missed.

Monte Carlo calculated output correction factors for Gafchromic EBT3 film for relative dosimetry in small stereotactic radiosurgery fields.

To calculate small field output correction factors, [Formula: see text], for Gafchromic EBT3 film using Monte Carlo simulations. These factors were determined for a Novalis Trilogy linear accelerator equipped with Brainlab circular cones with diameters of 4.0 to 30.0 mm. The BEAMnrc Monte Carlo code was used to simulate the Novalis Trilogy linear accelerator and the Brainlab cones with diameters 4.0 to 30 mm. The DOSXYZnrc code was used to simulate Gafchromic EBT3 film with the atomic composition specified by the manufacturer. Small field correction factors were calculated according to new IAEA TRS-483 Code of Practice for small field dosimetry. The depth of calculation was 10 cm and a source to surface distance of 100 cm. The X-ray beam used in the simulations was a 6 MV SRS. The correction factors were then used to determine field output factors with Gafchromic EBT3 film. These field output factors were validated using three solid state detectors and applying correction factors from the TRS-483 Code of Practice. The solid state detectors were IBA SFD diode, PTW 60018 SRS diode and PTW 60019 microDiamond. The Monte Carlo calculated output correction factors, [Formula: see text], for Gafchromic EBT3 film ranged between 0.998 to 1.004 for Brainlab circular cones with diameters between 4.0 and 30.0 mm. The uncertainty for these factors was 2.0%. The field output factors obtained with Gafchromic EBT3 film were within 2% of the mean results obtained with the three solid state detectors. For field sizes 4 mm diameter and above, Gafchromic EBT3 film has field output correction factors within 1% of unity. Therefore, Gafchromic EBT3 film can be considered to be correction less and supports the assumption made about this film in the TRS-483 Code of Practice.

Characteristics of inverse gamma histograms.

This work explores the characteristics of the inverse gamma histogram and its potential use as part of the patient specific quality assurance (PSQA) program for volumetric modulated arc therapy (VMAT). ArcCheck measured dose files and TPS predicted dose files were imported and analysed using the in-house inverse gamma code developed in the Python package. Inverse gamma with fixed distance-to-agreement of 2 mm were calculated for 23 VMAT arcs. Dose difference histograms were plotted for six arbitrarily selected arcs with the 95th and 90th percentile values calculated. Dose difference histograms enabled visualisation of the dose difference distribution information. The 95th and 90th percentile values are equivalent to the dose difference criteria where the gamma pass rate is 95% and 90% respectively. These values can be used as a guide to assess plan acceptability, especially for plans that failed the initial gamma evaluation. The inverse gamma histograms are demonstrated to be a useful tool for plan evaluation in addition to the traditional gamma evaluation method. It contains dose difference or distance-to-agreement distribution information, which could be clinically useful for plan evaluation.

Investigating the use of aperture shape controller in VMAT treatment deliveries.

BACKGROUND: Aperture shape controller (ASC) is a recently introduced leaf sequencer that controls the complexity of multileaf collimator apertures in the Photon Optimizer algorithm of the Eclipse treatment planning system. The aim of this study is to determine if the ASC can reduce plan complexity and improve verification results, without compromising plan quality. METHODS: Thirteen plans grouped into cohorts of head and neck/brain, breast/chest and pelvis were reoptimised using the same optimization as the non-ASC setting for low, moderate and high ASC settings. These plans were analyzed using plan quality indices such as the conformity index and homogeneity index in addition to dose-volume histogram based analysis on PTVs and organ at risks. Complexity assessments were performed using metrics such as average leaf pair opening, modulation complexity scores, relative monitor units (MU) and treatment time. Monitor unit per gantry angle variations were also analyzed. A third-party algorithm was also used to assess 3D dose distributions produced using the new leaf sequencer tool. Deliverability for the final multileaf collimator distribution was quantified using portal dose image prediction based gamma analysis. RESULTS: Plan conformality assessments showed comparable results and no significant plan degradation for plans reoptimised using ASC. Reduction in overall MU distributions were seen in some cases using higher ASC however, no overall trends were observed. In general, treatment deliverability, assessed using gamma analysis did not improve drastically however MU per degree distribution in 1 case improved when reoptimised using ASC. Treatment MUs generally reduced when ASC settings were used whilst in 1 case an increase in the treatment time factor > 1.8 was observed. The third-party algorithm assessment showed an underestimation of dose calculations for all cohorts used in this study when a higher ASC setting is used. CONCLUSIONS: The impact of using ASC in treatment plans was characterised in this study. Although plan complexity marginally improved when using higher ASC settings, no consensus could be reached based on metrics analyzed in this study. A reduction in MU distribution was observed with increasing ASC settings in most cases. This study recommends that ASC to be used as an additional tool only to test its suitability to reduce plan complexity.

In vivo monitoring of total skin electron dose using optically stimulated luminescence dosimeters.

AIM: This study retrospectively analysed the results of using optically stimulated radiation dosimeters (OSLDs) for in vivo dose measurements during total skin electron therapy (TSET, also known as TSEI, TSEB, TSEBT, TSI or TBE) treatments of patients with mycosis fungoides. BACKGROUND: TSET treatments are generally delivered to standing patients, using treatment plans that are devised using manual dose calculations that require verification via in vivo dosimetry. Despite the increasing use of OSLDs for radiation dosimetry, there is minimal published guidance on the use of OSLDs for TSET verification. MATERIALS AND METHODS: This study retrospectively reviewed in vivo dose measurements made during treatments of nine consecutive TSET patients, treated between 2013 and 2018. Landauer nanoDot OSLDs were used to measure the skin dose at reference locations on each patient, as well as at locations of clinical interest such as the head, hands, feet, axilla and groin. RESULTS: 1301 OSLD measurements were aggregated and analysed, producing results that were in broad agreement with previous TLD studies, while providing additional information about the variation of dose across concave surfaces and potentially guiding future refinement of treatment setup. In many cases these in vivo measurements were used to identify deviations from the planned dose in reference locations and to identify anatomical regions where additional shielding or boost treatments were required. CONCLUSIONS: OSLDs can be used to obtain measurements of TSET dose that can inform monitor unit adjustments and identify regions of under and over dosage, while potentially informing continuous quality improvement in TSET treatment delivery.

Impact of radiopacified bone cement on radiotherapy dose calculation.

BACKGROUND AND PURPOSE: Radiopacifiers are introduced to bone cements to provide the appearance of bone in kilovoltage (kV) radiographic images. For higher energy megavoltage (MV) radiotherapy treatment beams, however, these radiopacifiers do not cause a bone-like perturbation of dose. This study therefore aimed to determine the impact of the barium-contrasted plastic-based cement materials on radiotherapy dose calculations. MATERIALS AND METHODS: The radiological properties of a physical sample of bone cement were characterised by computed tomography (CT) imaging and transmission measurements. Monte Carlo simulations of percentage depth-dose profiles were performed to determine the possible dose error for MV treatment beams. Dose differences were then investigated for clinical volumetric modulated radiotherapy treatment plans, with and without density overrides applied. RESULTS: Differences of up to 7% were observed at the downstream interface of a 0.6 cm thick bone cement layer, compared to bone. Differences in planning target volume dose-volume metrics varied between -0.5% and 2.0%. CONCLUSION: Before planning radiotherapy treatments for patients who have undergone cranioplasty, every effort should be made to identify whether a radiopacified bone cement has been implanted. Density overrides should be applied to minimise dose calculation errors, whenever bone cement is used.

Analysis of dose comparison techniques for patient-specific quality assurance in radiation therapy.

PURPOSE: Gamma evaluation is the most commonly used technique for comparison of dose distributions for patient-specific pretreatment quality assurance in radiation therapy. Alternative dose comparison techniques have been developed but not widely implemented. This study aimed to compare and evaluate the performance of several previously published alternatives to the gamma evaluation technique, by systematically evaluating a large number of patient-specific quality assurance results. METHODS: The agreement indices (or pass rates) for global and local gamma evaluation, maximum allowed dose difference (MADD) and divide and conquer (D&C) techniques were calculated using a selection of acceptance criteria for 429 patient-specific pretreatment quality assurance measurements. Regression analysis was used to quantify the similarity of behavior of each technique, to determine whether possible variations in sensitivity might be present. RESULTS: The results demonstrated that the behavior of D&C gamma analysis and MADD box analysis differs from any other dose comparison techniques, whereas MADD gamma analysis exhibits similar performance to the standard global gamma analysis. Local gamma analysis had the least variation in behavior with criteria selection. Agreement indices calculated for 2%/2 mm and 2%/3 mm, and 3%/2 mm and 3%/3 mm were correlated for most comparison techniques. CONCLUSION: Radiation oncology treatment centers looking to compare between different dose comparison techniques, criteria or lower dose thresholds may apply the results of this study to estimate the expected change in calculated agreement indices and possible variation in sensitivity to delivery dose errors.

Departmental action limits for TQA energy variations defined by means of statistical process control methods.

The purpose of this study is to define departmental action limits for energy percentage variation measured by means of step-wedge helical Tomotherapy quality assurance module. Individual charts using the Statistical Process Control techniques have been used to identify retrospectively out-of-control situations ascribable to documented actions performed on the Tomotherapy system. Using the in-control data of our analysis process capability indices (cp, cpk, cpm and cpmk) are calculated in order to document the real working condition of the Tomotherapy system. Our findings indicate use of an action limit of 1.0% for energy percentage variation difference between the measured and reference output is a good working condition of a Tomotherapy system. cp and cpk indices are suggested as good indices that correctly report the system capability. A method for calculating and reporting Tomotherapy action limits for the integrated self-checking TQA energy check was shown in this study. SPC technique has proven to be efficient in defining departmental action limits from retrospective data for TQA energy measurements, hence optimally enabling corrective improvements in the process of quality assurance.